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Flutamide acts as a selective, competitive , silent antagonist of the androgen receptor (AR). [1] Its active metabolite , 2-hydroxyflutamide , has between 10- to 25-fold higher affinity for the AR than does flutamide, and hence is a more powerful antiandrogen in comparison. [1] [21] [46] [47] However, at high concentrations, unlike flutamide, 2-hydroxyflutamide is able to weakly activate the AR. [1] [48] Flutamide has far lower affinity for the AR than do steroidal antiandrogens like spironolactone and cyproterone acetate, and it is a relatively weak antiandrogen in terms of potency by weight, but the large dosages at which flutamide is used appear to compensate for this. [49] In accordance with its selectivity for the AR, flutamide possesses no progestogenic , (direct) estrogenic , glucocorticoid , or antigonadotropic activity. [25] [50] Similarly to nilutamide, bicalutamide, and enzalutamide , flutamide crosses the blood-brain-barrier and exerts central antiandrogen actions. [51]

It was once claimed in a magazine article that Palmie “punched and gouged his way from Paris to Toulouse” even when playing against mates. Wales hooker Bobby Windsor, hardly a shrinking violet himself, described the former Beziers and France second row as the hardest men he ever played against. “He would have to be No1,” said Windsor. “He’d boot anyone, any time. He’d give a quick look round to make sure the ref wasn’t looking and then, bang.” Palmie’s playing career ended in 1978 when he was banned for life for punching Armand Clerc, leaving the Racing Club player partially blinded in one eye. Went on to become an official in the French Rugby Federation!

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