Oxandrolone generic

Flutamide acts as a selective, competitive , silent antagonist of the androgen receptor (AR). [1] Its active metabolite , 2-hydroxyflutamide , has between 10- to 25-fold higher affinity for the AR than does flutamide, and hence is a more powerful antiandrogen in comparison. [1] [21] [46] [47] However, at high concentrations, unlike flutamide, 2-hydroxyflutamide is able to weakly activate the AR. [1] [48] Flutamide has far lower affinity for the AR than do steroidal antiandrogens like spironolactone and cyproterone acetate, and it is a relatively weak antiandrogen in terms of potency by weight, but the large dosages at which flutamide is used appear to compensate for this. [49] In accordance with its selectivity for the AR, flutamide possesses no progestogenic , (direct) estrogenic , glucocorticoid , or antigonadotropic activity. [25] [50] Similarly to nilutamide, bicalutamide, and enzalutamide , flutamide crosses the blood-brain-barrier and exerts central antiandrogen actions. [51]

Oxandrolone generic

oxandrolone generic

Media:

oxandrolone genericoxandrolone genericoxandrolone genericoxandrolone genericoxandrolone generic