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Because weight loss typically consists of both fat and lean tissue, measurement of body composition for diagnostic purposes, although potentially useful, is not essential. Although several early studies demonstrated that mortality is related not just to loss of weight but also to depletion of lean tissue, a recent study performed in patients on ART suggested that weight loss was a better predictor of mortality than lean or fat tissue measured by bioelectric impedance.( 13 ) Nonetheless, there has been considerable interest in the measurement of body composition in patients with HIV infection, and such measurements can be useful in conjunction with well-maintained weight records to characterize an individual's response to various medical or nutritional interventions.

An orexigenic , or appetite stimulant , is a drug , hormone , or compound that increases appetite . This can be a naturally occurring neuropeptide hormone such as ghrelin , orexin or neuropeptide Y , [1] [2] or a medication which increases hunger and therefore enhances food consumption . Usually appetite enhancement is considered an undesirable side effect of certain drugs as it leads to unwanted weight gain , [3] [4] [5] but sometimes it can be beneficial and a drug may be prescribed solely for this purpose, especially when the patient is suffering from severe appetite loss or muscle wasting due to cystic fibrosis , anorexia , old age , cancer or AIDS . [6] [7] [8] [9] [10] There are several widely used drugs which can cause a boost in appetite, including tricyclic antidepressants (TCAs), tetracyclic antidepressants , natural or synthetic cannabinoids , first-generation antihistamines , most antipsychotics and many steroid hormones .

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