Oxandrin and Anadrol-50 are both oral anabolic steroids approved by the Food and Drug Administration (FDA), and they are competing for market share in the world of HIV treatments. Both are described as "open label" drugs and as such, are prescribed to reverse wasting and metabolic complications associated with HIV. Anadrol-50 is among the most potent steroids ever developed for building muscle, and study participants gained an average of pounds for each 100 pounds of weight. Early studies indicate minimal side effects with liver toxicity, but that is not a certainty since oral anabolics are known for liver toxicity. Many studies have documented Oxandrin's safety and effectiveness in treating HIV wasting. It is metabolized in the kidney and acts without the masculinizing side effects associated with other steroids, such as Anadrol-50. One study showed an average weight gain of 24 pounds following 8 months of treatment. Oxandrin is the best choice for those at the earliest stages of AIDS wasting syndrome. However, when a more aggressive treatment is necessary, Anadrol-50 is stronger, less expensive, and more effective, but liver function must be monitored closely.