Testosterone interacts readily with the enzyme aromatase, which results in estrogen conversion. High circulatory levels of estrogen can lead to a number of issues including gynecomastia (the formation of male breast tissue, often referred to in slang terms as 'gyno' or 'bitch tits'), water retention and fat deposition. It is clear that some users are much more sensitive to the effects of increased estrogen levels than others, and may notice typical early signs of the condition even from using a very modest dose of testosterone such as 500mg weekly. The user should recognise these early warning signs which can be just one or a culmination of: swollen, puffy, painful, lumpy, itchy or tender nipples. Should any of these symptoms become apparent, it would be prudent to control both existing circulating estrogen and the level of future estrogen conversion. This is achieved through the use of a Selective Estrogen Receptor Modulator (SERM) such as Tamoxifen (brand name Nolvadex) which, being a weak estrogen in itself will compete and occupy the breast tissue estrogen receptor rendering much of the troublesome circulating estrogen inert, and by the use of an anti-estrogen drug such as Proviron or Arimidex. These assist by binding and therefore blocking the effects of the enzyme responsible for estrogenic conversion, thereby reducing actual circulating estrogen levels. For more information see the article Combating Oestrogens and Progesterone .
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However, this perception of increased strength and power had commonly been desired by all athletes who had practiced the self administration of this compound, as this sensation had usually been indicative that the compound of Anapolon had indeed, been performing to it's full capacity. Several athletes had also claimed that another distinguishing trait of Anapolon, had been the increased training duration's, as this compound had been able to have stimulated the regeneration of the body, which often had enabled further muscle building progress, and had stalled the possibility of over training.